Ny cancerhypotes

Ny cancerhypotes

Via australiensiska LifeScientist så får vi reda på att forskare nu har presenterat en ny .

Vi tror att de tumörer som utvecklas hos cancerpatienter i dag har samma form som dessa enkla cellstrukturer gjorde mer än en miljard år sedan

Enligt uppsatsens sammandrag:

The genes of cellular cooperation that evolved with multicellularity about a billion years ago are the same genes that malfunction to cause . We hypothesize that is an atavistic condition that occurs when genetic or epigenetic malfunction unlocks an ancient ’toolkit’ of pre-existing adaptations, re-establishing the dominance of an earlier layer of genes that controlled loose-knit colonies of only partially differentiated cells, similar to tumors. The existence of such a toolkit implies that the progress of the neoplasm in the host organism differs distinctively from normal Darwinian evolution. Comparative genomics and the phylogeny of basal metazoans, opisthokonta and basal multicellular eukaryotes should help identify the relevant genes and yield the order in which they evolved. This order will be a rough guide to the reverse order in which develops, as mutations disrupt the genes of cellular cooperation. Our proposal is consistent with current understanding of and explains the paradoxical rapidity with which acquires a suite of mutually-supportive complex abilities. Finally we make several predictions and suggest ways to test this model.

Denna hyptes är framtagen av , Arizona State University samt , Australian National University.

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